Pembroke Welsh Corgi
Pembroke Welsh Corgi
the Red Dragon
Pembroke Welsh Corgi
the Red Dragon
 Quality in a small package
Pembroke Welsh Corgi
the Red Dragon
 Quality in a small package
Y DDRAIG GOCH
Pembroke Welsh Corgi
the Red Dragon
Y DDRAIG GOCH
 Quality in a small package
The official statement of the Welsh Corgi League regarding Degenerative Myelopathy (DM) 2018
 
 
In response to the comments on social media in respect of Degenerative Myelopathy (DM). The League are well aware of this condition and have monitored the research for this condition for several years and until a conclusive test has been established which currently there isn’t.
The League do not want to recommend breeders test their breeding stock until there is a conclusive test.
 
This condition has been in the breed for many years and has been the subject of extensive research in the USA. DM can affect the older Corgi causing it to go off its hind legs. The gene responsible for DM has been identified but it is not a ‘cut and dry’ situation, as a dog can show as ‘affected’ ‘carrier’ or ‘clear’, however these are showing the potential risk, meaning an 'affected' dog from the genes will not necessarily ever express the condition, and only give a potential risk for that individual.  Currently the only way a dog can be diagnosed with having DM is after death and the spinal cord is removed for investigation.
 
There is currently no reliable way of diagnosis when the dog is alive. Communicating with a prominent breeder in the USA to see if breeders are testing their breeding stock prior to breeding, the response was No they are not as the test is NOT a conclusive predictor of DM in Pembroke’s. While 96% of all Pembroke’s tested are “AT Risk”, only about 6% of Pembroke’s actually present with the disease.
 
The problem is that there are multiple factors which, when present, the “At Risk” Pembroke’s will present with the disease. As of right now, there is no test for this other factors. However, there is news that the researchers are close to figuring it out. So, hopefully, we will have a more definitive test soon. In the meantime, Dr. Jerry Bell, a well-known Veterinarian Geneticist, in the USA has said publicly, “Anyone who makes breeding decisions on the current DM available, is FOOLISH.” The Welsh Corgi League supports the Give a Dog a Gnome a collaboration between the Kennel Club and the Animal Health Trust by donating £1000 for research into DM. This was matched with a donation of £1000 from the Kennel Club. The AHT is working with Prof. Gary Johnson a neurologist at the University of Missouri. From the information currently available asking breeders to test their breeding stock prior to breeding and buyers insisting puppies be tested is not the answer to eradicating DM in the breed more a case of throwing the baby out with the bath water. Intervertebral Disc Disease (IVDD) has similar symptoms to DM which is another confounding factor in diagnosis, as mentioned earlier the only definite diagnosis of DM is after death. DM is a progressive disease of the spinal cord in older dogs. A recessive mutation that is linked with this disease has been identified. There is evidence that having two copies of this gene (one inherited from the mother and one from its father) is strongly associated with the development of DM. However, having two copies of the recessive mutant gene does not necessarily result in clinical disease and similarly an absence of the gene is not a guarantee that the condition will not occur. This is known as incomplete penetrance.
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• Two copies of the normal gene (“Clear”/ homozygous normal) – likely to be free of DM
• One copy of the mutant gene (“carrier”/ heterozygous) – low chance of developing the disease
• Two copies of the mutant gene (“affected”/ homozygous affected) – high risk of developing DM.
 

Further information on different forms of inheritance available here: https://www.thekennelclub.org.uk/…/…/traits-and-inheritance/

DM is a complicated condition genetically, and a global problem in the breed. It is therefore critical that a robust diagnosis is obtained before making haste decisions.
 
Diana King
Health Co-ordinator
Welsh Corgi Pembroke

Wed, 3rd March 2021
06:20:57

Y Ddraig Goch

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  • Last Updated: Sunday 28 February 2021, 11:50:10.
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